LATE

Noun

1. Acronym of limbic-predominant age-related TDP-43 encephalopathy, a form of dementia.
   • We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a stereotypical TDP-43 proteinopathy in older adults,...
   • The clinical entity LATE (limbic-predominant age-related TDP-43 encephalopathy) has recently emerged. - 2020 March, Daniel Ferreira, Agneta Nordberg, Eric Westman, “Biological subtypes of Alzheimer disease: A systematic...
   • The framework of LATE would account for the pathogenetic impact of limbic TDP-43 proteinopathy as a driver of amnestic dementia, either together with comorbid typical AD changes or as a distinct feature. - 2020 May 14,...